The 49ers host the Jaguars in a Week 4 matchup of the 2025 NFL season at Levi’s Stadium on Sunday.
San Francisco continued without Brick Purdy in Week 3. They have managed to hold on to a 3-0 start, beating the Cardinals in a narrow 16-15 win while the Jaguars beat the Texans 17-10 to move, improving to a 2-1 record.
There’s a lot of uncertainty around the quarterback for Week 4 when it comes to the 49ers, as Mac Jones, who filled in for Purdy, is now sidelined with a knee injury.
On the other hand, the Jaguars make the trip to San Francisco, where they have never won a game. Even in all-time series, they trail 2-5 despite winning in their first two meetings back in 1999 and 2005.
Here’s how you can watch 49ers vs. Jaguars, including TV and live stream information for the game.
Where to watch 49ers vs. Jaguars today: TV channel, live stream
- TV channel: Fox
- Live stream: Fubo
49ers vs. Jaguars will air nationally on Fox, with Adam Amin (play-by-play) and Mark Sanchez (analyst) on the call.
Fans can stream the game live with Fubo, which offers a free trial for new subscribers, so you can try the service before you buy. Stream ESPN, ABC, CBS, Fox, NBC and 100+ top channels of live TV and sports without cable. (Participating plans only. Taxes and fees may apply.)
49ers vs. Jaguars start time
- Date: Sunday, Sept. 28
- Time: 4:25 p.m. ET
49ers vs. Jaguars will kick off at 4:25 p.m. ET on Sunday, Sept. 28. The game will be played at Levi’s Stadium in Santa Clara, California.
49ers vs. Jaguars radio station
Fans can listen to the 49ers vs. Jaguars live with SiriusXM. For team-specific calls, head to channel 226 (San Francisco 49ers broadcast) and channel 381 (Jacksonville Jaguars broadcast).
New subscribers get their first month of SiriusXM for free. Listen to every NFL game live, plus college football, MLB, NBA, NHL, NASCAR and more. Stay updated with all the news and analysis from SiriusXM NFL Radio and other sport-specific channels.
49ers schedule 2025
Here’s a look at San Francisco’s upcoming schedule.
| Date | Game | Time | TV/Live stream |
|---|---|---|---|
| Sept. 7 | 49ers 17, Seahawks 13 | — | — |
| Sept. 14 | 49ers 26, Saints 21 | — | — |
| Sept. 21 | 49ers 16, Cardinals 15 | — | — |
| Sept. 28 | vs. Jaguars | 4:05 p.m. | FOX |
| Oct. 2 | at Rams | 8:15 p.m. | Prime Video |
| Oct. 12 | at Buccaneers | 1 p.m. | CBS |
| Oct. 19 | vs. Falcons | 8:20 p.m. | NBC |
| Oct. 26 | at Texans | 1 p.m. | FOX |
| Nov. 2 | at Giants | 1 p.m. | CBS |
| Nov. 9 | vs. Rams | 4:25 p.m. | FOX |
| Nov. 16 | at Cardinals | 4:05 p.m. | FOX |
| Nov. 24 | vs. Panthers | 8:15 p.m. | — |
| Nov. 30 | at Browns | 1 p.m. | CBS |
| Dec. 14 | vs. Titans | 4:25 p.m. | FOX |
| Dec. 22 | at Colts | 8:15 p.m. | — |
| Dec. 28 | vs. Bears | 8:20 p.m. | NBC |
| TBD | vs. Seahawks | TBD | — |
Jaguars schedule 2025
Here’s a look at Jacksonville’s upcoming schedule.
| Week | Date | Game | Time (ET) |
| 1 | Sun., Sept. 7 | Jaguars 26, Panthers 10 | — |
| 2 | Sun., Sept. 14 | Bengals 31, Jaguars 27 | — |
| 3 | Sun., Sept. 21 | Texans 10, Jaguars 17 | 1 p.m. |
| 4 | Sun., Sept. 28 | at 49ers | 4:05 p.m. |
| 5 | Mon., Oct. 6 | vs. Chiefs | 8:15 p.m. |
| 6 | Sun., Oct. 12 | vs. Seahawks | 1 p.m. |
| 7 | Sun., Oct. 19 | vs. Rams | 9:30 a.m. |
| 8 | BYE | – | – |
| 9 | Sun., Nov. 2 | at Raiders | 4:05 p.m. |
| 10 | Sun., Nov. 9 | at Texans | 1 p.m. |
| 11 | Sun., Nov. 16 | vs. Chargers | 1 p.m. |
| 12 | Sun., Nov. 23 | at Cardxinals | 4:05 p.m. |
| 13 | Sun., Nov. 30 | at Titans | 1 p.m. |
| 14 | Sun., Dec. 7 | vs. Colts | 1 p.m. |
| 15 | Sun., Dec. 14 | vs. Jets | 1 p.m. |
| 16 | Sun., Dec. 21 | at Broncos | 4:05 p.m. |
| 17 | Sun., Dec. 28 | at Colts | 1 p.m. |
| 18 | TBD | vs. Titans | TBD |
NFL Week 4 schedule
Here’s a complete look at the NFL schedule for Week 4 of the new season, with games spread out across three days.
Thursday, Sept. 25
| Game | Time (ET) | TV channel |
|---|---|---|
| Seahawks at Cardinals | 8:15 p.m. | Prime Video |
Sunday, Sept. 28
| Game | Time (ET) | TV channel |
|---|---|---|
| Vikings vs. Steelers | 9:30 a.m. | NFL Network |
| Commanders at Falcons | 1 p.m. | CBS |
| Saints at Bills | 1 p.m. | CBS |
| Browns at Lions | 1 p.m. | FOX |
| Titans at Texans | 1 p.m. | CBS |
| Panthers at Patriots | 1 p.m. | FOX |
| Chargers at Giants | 1 p.m. | CBS |
| Eagles vs. Buccaneers | 1 p.m. | FOX |
| Colts at Rams | 4:05 p.m. | FOX |
| Jaguars at 49ers | 4:25 p.m. | FOX |
| Ravens vs. Chiefs | 4:25 p.m. | CBS |
| Bears vs. Raiders | 4:25 p.m. | CBS |
| Packers vs. Cowboys | 8:20 p.m. | NBC |
Monday, Sept. 29
| Game | Time (ET) | TV channel |
|---|---|---|
| Jets at Dolphins | 7:15 p.m. | ESPN |
| Bengals at Broncos | 8:15 p.m. | ABC |
