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Every weekend during the NFL season, fantasy football players must stay on top of the latest news. This especially matters on Sundays, when the league releases the injury and inactive reports for every game.

Below, you’ll find Week 6 start-sit lineup recommendations to help you make early decisions on who to start in your fantasy league.

We’re starting our running, live tracker of the latest fantasy news you need to know each Sunday morning, leading into 1 p.m. ET NFL game kickoffs.

Scroll down for our latest news updates and strategy tips to help you set your fantasy lineups.

FANTASY LINEUP TIPS: Week 6 Sleepers | Week 6 Busts | Week 6 Waiver Wire

Who should I start in fantasy Week 6?

Click to read Vinnie Iyer’s full Week 6 Start ‘Em Sit ‘Em.

Fantasy lineup Week 6 questions answered, for half-PPR start-sit lineup tips:

Fantasy Football Week 6 Must-Starts

QB: Josh Allen, Bills (at ATL), Dak Prescott, Cowboys (at CAR), Jayden Daniels, Commanders (vs. CHI), Patrick Mahomes, Chiefs (vs. DET), Baker Mayfield, Buccaneers (vs. SF), Justin Herbert, Chargers (at MIA), Drake Maye, Patriots (at NO)

RB: Jonathan Taylor, Colts (vs. ARI); Josh Jacobs, Packers (vs. CIN); Bijan Robinson, Falcons (vs. BUF); Christian McCaffrey, 49ers (at TB); Jahmyr Gibbs, Lions (at KC); Ashton Jeanty, Raiders (vs. TEN); De’Von Achane, Dolphins (vs. LAC); James Cook, Bills (at ATL); Quinshon Judkins, Browns (at PIT); Javonte Williams, Cowboys (at CAR); Kyren Williams, Rams (at BAL); Rico Dowdle, Panthers (vs. DAL); J.K. Dobbins, Broncos (vs. NYJ); Jacory Croskey-Merritt, Commanders (vs. CHI); Travis Etienne, Jaguars (vs. SEA); Tony Pollard, Titans (at LV); Derrick Henry, Ravens (vs. LAR); David Montgomery, Lions (at KC); Kenneth Walker III, Seahawks (at JAX)

WR: Puka Nacua, Rams (at BAL); Amon-Ra St. Brown, Lions (at KC); Jaxson Smith-Njigba, Seahawks (vs. TB); Emeka Egbuka, Buccaneers (vs. SF); Rome Odunze, Bears (at WAS); Davante Adams, Rams (at BAL); Ja’Marr Chase, Bengals (at GB); George Pickens, Cowboys (at CAR); Deebo Samuel, Commanders (vs. CHI – if active); Tetairoa McMillan, Panthers (vs. DAL); Xavier Worthy, Chiefs (vs. DET); Jaylen Waddle, Dolphins (vs. LAC); DK Metcalf, Steelers (vs. CLE); Drake London, Falcons (vs. ATL); Marvin Harrison Jr., Cardinals (at IND);  Quentin Johnston, Chargers (at MIA – if he plays); Keenan Allen, Chargers (vs. MIA); Ladd McConkey, Chargers (at MIA); Brian Thomas Jr., Jaguars (vs. SEA); Tee Higgins, Bengals (at GB)

TE: Jake Ferguson, Cowboys (at CAR); Tucker Kraft, Packers (vs. CIN); Tyler Warren, Colts (vs. ARI; Trey McBride, Cardinals (at IND); Travis Kelce, Chiefs (vs. DET); Dalton Kincaid, Bills (at ATL); Sam LaPorta, Lions (at KC)

D/ST: Green Bay Packers (vs. CIN); Pittsburgh Steelers (vs.CLE); Los Angeles Rams (at BAL); Jacksonville Jaguars (vs. SEA); Cleveland Browns (at PIT); Las Vegas Raiders (vs. TEN); Indianapolis Colts (vs. ARI); Dallas Cowboys (at CAR); Buffalo Bills (at ATL); New England Patriots (at NO); Tennessee Titans (at LV); Detroit Lions (at KC)

Fantasy Football Week 6 Start ‘Em

QB: Matthew Stafford, Rams (at BAL); Daniel Jones, Colts (vs. ARI); Jordan Love, Packers (vs. CIN); Caleb Williams, Bears (at WAS); Bo Nix, Broncos (vs. NYJ); Mac Jones, 49ers (at TB – if he plays)

RB: Rachaad White, Buccaneers (at SF); Rhamondre Stevenson, Patriots (at NO); Hassan Haskins, Chargers (at MIA); Zach Charbonnet, Seahawks (at JAX); Kareem Hunt, Chiefs (vs. DET)

WR: Zay Flowers, Ravens (vs. LAR — if active); Calvin Ridley, Titans (at LV); Chris Olave, Saints (vs. NE); Kendrick Bourne, 49ers (at TB); Michael Pittman Jr., Colts (vs. ARI); Stefon Diggs, Patriots (at NO); DJ Moore, Bears (at WAS); Rashid Shaheed, Saints (vs. NE)

TE: David Njoku, Browns (at PIT); Juwan Johnson, Saints (vs. NE); Hunter Henry, Patriots (at NO); Brenton Strange, Jaguars (vs. SEA); Darren Waller, Dolphins (vs. LAC)

Fantasy Football Week 6 Sit ‘Em

QB: Bryce Young, Panthers (vs. DAL);  Trevor Lawrence, Jaguars (vs. SEA); Justin Fields, Jets (vs. DEN); Kyler Murray, Cardinals (at IND, if active); Aaron Rodgers, Steelers (vs. CLE); Jared Goff, Lions (at KC)

RB: Alvin Kamara, Saints (vs. NE, if he plays); Chase Brown, Bengals (at GB); Kenneth Gainwell, Steelers (vs. CLE); D’Andre Swift, Bears (at WAS); Michael Carter, Cardinals (at IND); TreVeyon Henderson, Patriots (at NO)

WR: Jameson Williams, Lions (at KC); Jakobi Meyers, Raiders (at IND); Khalil Shakir, Bills (vs. NE); Jerry Jeudy, Browns (at PIT); Romeo Doubs, Packers (at CIN); Matthew Golden, Packers (at CIN)

TE: Jake Tonges, 49ers (vs. TB);  Zach Ertz, Commanders (vs. CHI); Mark Andrews, Ravens (vs. LAR); Mason Taylor, Jets (vs. DEN); Kyle Pitts, Falcons (vs. BUF); Harold Fannin Jr., Browns (at PIT)

NFL Fantasy Week 6 Inactives

Inactive fantasy players expected to be OUT for Week 6

These fantasy names are among either those listed on injured reserve, listed as OUT, or not expected to play this week. Remove them from your Week 6 lineups once confirmed.

To check every player practice report and health designation every week, bookmark our NFL injuries tracker.

• Kyler Murray, QB, Cardinals-NOT EXP TO PLAY
• Lamar Jackson, QB, Ravens – OUT
• Chuba Hubbard, RB, Panthers – OUT
• Bucky Irving, RB, Buccaneers – OUT
• CeeDee Lamb, WR, Cowboys – OUT
• Mike Evans, WR, Buccaneers – OUT
• Brock Bowers, TE, Raiders – OUT
• Brock Purdy, QB, 49ers – OUT
• Ricky Pearsall, WR, 49ers – OUT
• Jalen Coker, WR, Panthers – OUT
• Terry McLaurin, WR, Commanders (MNF) – OUT
• Omarion Hampton, RB, Chargers – IR-R

NFL Fantasy Week 6 Players ACTIVE, EXPECTED TO PLAY, or QUESTIONABLE

These fantasy names are expected to play in Week 6, but confirm their status before locking them into your lineups:

Early-window injuries

• Alvin Kamara, RB Saints
• Quentin Johnston, WR, Chargers
• Zay Flowers, WR, Ravens
• Jaylen Warren, RB, Steelers
• Tutu Atwell, WR, Rams

Late-Window and SNF injury statuses to watch

• Jauan Jennings, WR, 49ers
• Xavier Worthy, WR, Chiefs

Week 6 fantasy players on bye

Take these typical or occasional fantasy starters out of your lineups: 

Houston Texans

• WR Nico Collins
• RB Nick Chubb
• RB Woody Marks
• QB CJ Stroud
• TE Dalton Schultz

Minnesota Vikings

• WR Justin Jefferson
• RB Jordan Mason
• WR Jordan Addison
• TE T.J Hockenson
• QB Carson Wentz (J.J. McCarthy injured)

Top Week 6 fantasy news for Sunday

Watch for updates on major fantasy news for Week 6.

Hassan Haskins will lead Chargers’ backfield

In the first week with Omarion Hampton (ankle) on injured reserve (designated to return), the Bolts will turn to Haskins as the No. 1 running back, per NFL Network’s Mike Garafolo. 

However, the Bolts may be on the lookout across the trade market for a bigger name with the assumption that Hampton’s recovery may take nearly two months:

From @NFLGameDay with The Insiders on the #Chargers nosing around the trade market for a running back with Omarion Hampton expected to be sidelined longer than the four-week IR minimum. pic.twitter.com/XUegDWT1ga

— Mike Garafolo (@MikeGarafolo) October 12, 2025

Kimani Vidal probably will still mix in for Week 6 as a passing-situation back, but Haskins (6-foot-2, 228 pounds) has the best shot at goal-line and red-zone work due to this size. 

• Haskins: a fantasy RB2 | Vidal: low-end flex play, better in PPR

Bam Knight will start for Cardinals RBs

Michael Carter’s demotion doesn’t necessarily mean Knight is the unquestioned, majority player, though Emari Demercado’s major fumble mistake last Sunday might’ve cost him a decent share of backfield touches.

Knight (5-foot-11, 210 pounds) does have the build for between-the-tackles and goal-line work, so he may wind up seizing the majority of those reps, with Demercado and Carter taking many pass-catching snaps.

Desperate for a flex? Say BAM.

Brock Bowers’ return likely will be Week 9, at the earliest 

NFL Network’s Tom Pelissero reports that the Raiders’ tight end likely will not return from his knee injury until after the Raiders’ Week 8 bye, which means he’ll also sit out in Week 7. 

Fantasy players should make other long-term plans at tight end. We’ll keep tabs on the best pickups each week in our waiver wire.

Week 6 fantasy rankings

This week’s fantasy football rankings were updated Friday at 6 p.m. ET.

We’ve based these fantasy football rankings on full-point PPR scoring except where otherwise noted.

Note: Players or teams who have already participated in their game this week will have – TNF or – London next to their names.

Week 6 Fantasy QB Rankings 

Week 6 Fantasy RB Rankings (PPR)

Week 6 Fantasy WR Rankings (PPR)

Week 6 Fantasy TE Rankings (PPR)

Week 6 Fantasy Defense Rankings

Week 6 Fantasy Kicker Rankings

Week 6 Fantasy Half-PPR RB/WR/TE Flex Rankings

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NFL Weather Week 6: Fantasy updates and players affected

No immediate weather concerns for NFL fantasy exist as of Sunday, 10 a.m. ET.